Spray Cryotherapy for Pulmonary Applications

Tracheal & Bronchial Stenosis

trūFreeze spray cryotherapy is a non-contact and regenerative therapeutic treatment for benign airway diseases such as tracheal and bronchial stenosis. Studies have shown that cryotherapy combined with balloon dilation significantly improved luminal caliber and often a more extended period before reintervention.

Case Report – Concentric Tracheal Stenosis

After a lengthy intubation, the patient experienced the insidious onset of dyspnea and presented with stridor and hemoptysis. During treatment for hemoptysis, a benign concentric growth restricting the trachea to 7mm diameter (60% obstructed) was discovered.¹²

Four months after the first procedure, the airway measures 14mm (82% patent); the patient is asymptomatic and requires no intervention. Learn more about treating tracheal stenosis with spray cryotherapy with the studies provided in the references section of this page.^{1, 2}

• Link to Reference 1
• Link to Reference 2
• Link to Reference 12

Malignancies & Tumor Burden

Liquid Nitrogen Spray Cryotherapy (LNSC) is a non-contact cryoablation that uses rapid freezing and thawing of tissue to cause cellular death and can help manage bleeding when treating airway malignancies.³

• Link to Reference 3

Respiratory Papillomatosis

An emerging application for cryotherapy is treating Recurrent Respiratory Papillomatosis (RRP), a rare disorder characterized by the development of small, wart-like growths (papillomas) in the respiratory tract that can be challenging to treat.

In one case study, the patient was treated with debridement followed by multiple cryotherapy treatments, resulting in the resolution of symptoms.^{4, 5}

• Link to Reference 4
• Link to Reference 5

Lung Transplant Anastomotic Strictures

Tim Cox shares how trūFreeze^® Cryotherapy "gave him his life back." Tim experienced severe bronchial stenosis following a double lung transplant. His quality of life was low due to the frequent bronchoscopies, stents, and dilation treatments.

Listen as Tim explains how he has hope again following his Spray Cryotherapy procedures. His Interventional Pulmonologist has removed all five stents, and Tim is breathing better with longer intervals between treatments.

• See References

Stent Management

Spray cryotherapy can be a tool to help manage granulation formation and epithelialized stents that require removal from the airway.⁶

• Link to Reference 6

Leukoplakia

An emerging application for cryotherapy is treating leukoplakia of the vocal cords. In this case, the abstract accepted at the World Congress of Bronchoscopy, spray cryotherapy was used to treat hyperkeratosis and leukoplakia of the bilateral vocal folds.

View the first report of endoscopic Spray Cryotherapy (SCT) use in treating severe vocal fold leukoplakia.

• See References