Active Venting Solutions – Rapid AV™ Catheter

Product Overview

The Rapid AV Catheter is designed for use in procedures requiring active venting, such as spray cryotherapy in gastrointestinal (GI) endoscopy cases.

The Rapid AV Catheter Technology

The Rapid AV catheter is primarily used in gastrointestinal procedures that require active venting to ablate benign disease and malignancies such as esophageal cancer. The catheter is specially designed to deliver cold LN2 at -196°C to cause a fast freeze and allow for a slow thaw of the tissue. This fast freeze and slow thaw cycle effectively kills tissue by causing instant and delayed cell death for a more effective treatment of diseased cells of the tissue.

How the Rapid AV Catheter and Active Venting Cryotherapy Works

The Rapid AV catheter is designed for the delivery of spray cryotherapy treatment for Barrett’s esophagus and spray cryotherapy for esophageal cancer – utilizing an active venting method. This specially designed catheter features decreased time to frost by 50%, minimizing overall ablation time.

Examples of additional benign and malignant applications include:

• Hemostasis
• Stricture Management
• Stent overgrowth/ingrowth
• Radiation proctitis
• Dysphagia
• Gastric Antral Vascular Ectasia (GAVE)
• Diseases of the high cardia

Why the Rapid AV Catheter?

Benefits of the Rapid AV Catheter include:

• 50% reduction in overall ablation time – The Rapid AV catheter is designed to decrease time to frost by 50%
• Treats benign and malignant lesions – the truFreeze system is the only device indicated to ablate Barrett's Esophagus with high grade dysplasia and/or low-grade dysplasia and malignancies
• Rejuvenative healing response – Liquid nitrogen spray cryotherapy promotes a rejuvenative healing response due to low scarring compared to traditional heat-based ablation therapies.

Clinical Data

Published Studies

Many peer-reviewed studies have been published in support of cryotherapy ablation. Several recent studies shown below are great references for those looking to learn about this treatment. Explore the full Active Venting Bibliography for more information.

Case Studies

Barrett’s Esophagus with High Grade Dysplasia:

In a recent study showing long-term results over five years, 93% of patients achieved complete eradication of high-grade dysplasia (CE-HGD). 88% achieved complete eradication of dysplasia (CE-D) and 75% achieve complete eradication of intestinal metaplasia (CE-IM).¹

Relief of Dysphagia in Advanced Esophageal Cancer:

In a multicenter trial of 49 patients with inoperable esophageal cancer, liquid nitrogen cryotherapy showed statistically significant improvement in patients’ dysphagia (difficulty swallowing) taking them from an MDS (Mean Dysphagia Score) of 2.4 to 1.7 on the 4-point Likert scale. Further, the study suggests that liquid nitrogen cryotherapy may be safe and effective for dysphagia palliation in inoperable esophageal cancer.²

¹ Ramay FH, et al. “Outcomes after liquid nitrogen spray cryotherapy in Barrett's esophagus-associated high-grade dysplasia and intramucosal adenocarcinoma: 5-year follow-up.” Gastrointestinal Endoscopy. 2017 Oct;86(4):626-632.

² Kachaamy K, et. al. “Liquid nitrogen spray cryotherapy for dysphagia palliation in patients with inoperable esophageal cancer”, Gastrointestinal Endoscopy 2018, Volume 88, No. 3, p. 447-455.

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Videos

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Literature

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